Brain health is a major concern in the future of society.
Researchers have been trying to find ways to improve brain function, but this can lead to complications including stroke, Alzheimer’s disease, and even death.
Now, a group of scientists have developed a novel drug to help restore function in people with degenerative brain disease.
The drug, called piroxicam, has a long history of use in patients with stroke, but its development has been hampered by the fact that the drug requires an external injection and has a limited number of users.
In a paper published in the journal PLOS ONE, researchers at the University of California, Berkeley and UC San Francisco have developed pirooxidase inhibitors to target a new class of drug that is used in Parkinson’s disease.
In the study, researchers showed that piroXicam reduces the risk of stroke by 30% and reduces the progression of Parkinson’s by up to 50%.
“We hope that this will enable the development of a safer, more effective therapy for patients who are currently struggling to get out of bed,” said co-author and postdoctoral fellow Daniel J. Henn, PhD. “We also hope that our results will be useful in helping to address the growing body of research on the potential of piroxiocin as a novel treatment for Parkinson’s.”
The research was supported by the National Institutes of Health (grant number NIN-10R01MH098145).
“These findings provide a critical platform for further development of novel piroxiaicam-based therapies for Parkinson disease,” said Dr. Richard B. Littman, MD, professor of psychiatry at UC San Diego.
“These promising results are important because we have so many questions about the effectiveness of puroXicams treatment for patients with Parkinson’s.
What about the long-term consequences of peroXicoms use?”
The study was published online June 10, 2017.
A video of Dr. Hernán Piroxico and Dr. Jérémie Célestin discussing the study is available on YouTube.
Image credit: UCLA/Katherine L. Jones/University of California